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EC number: 201-549-0
CAS number: 84-65-1
test substance, Anthraquinone, was tested in the study for acute dermal
irritation /corrosion. Rabbits (New Zealand Albino breed) were used for
was performed according to Method B.4 - Acute Toxicity: Dermal
Irritation/Corrosion, Council Regulation (EC) No.440/2008, published in
O.J. L 142, 2008.
rabbits were exposed to 0.5 g of test substance, applied onto clipped
skin for 4 hours using a semi-occlusive dressing. Skin reactions were
evaluated after patch removal and observations were made at 1, 24, 48
and 72 hours after exposure.
first the test substance was applied on the skin of one rabbit (test
animal No. 7). Rabbit No. 7 was investigated 3 minutes, 1 hour and 4
hours after application of the test substance. No symptoms of irritation
were observed on the skin. In confirmatory test, two others rabbits
(rabbit No. 8 and No. 9) were used with 4-hour exposition period. No
evidence of a corrosive effect or symptoms of irritation were observed
on the skin.
skin irritation was caused by 4-hour exposure to Anthraquinone. No other
signs of intoxication were observed.
on these results and according to the EC criteria for classification and
labelling requirements for dangerous substances and preparations
(Council Directive 67/548/EEC, Annex VI, part 188.8.131.52.), the test
substance does not have to be classified for skin irritation and has no
obligatory labelling requirement for skin irritation.
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