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EC number: 201-549-0
CAS number: 84-65-1
The mating, fertility, and fecundity
indices (83.3-100%) for both treated males and females were unaffected
by treatment with Anthraquinone and were similar to controls
(91.7-100.0%). Likewise, the copulatory interval (days to mating) was
unaffected by treatment and ranged from 2.4-3.1 days in the treated
groups in comparison to 3.0 in the controls.
No macroscopic observations were evident
in any pups at necropsy. At 150 mg/kg/day, no effect of treatment was
evident from parturition data, litter size, or pup survival to LD 4. No
test article-related organ weight changes were noted in rats of either sex.
Samples (2.0 mL) of the dosing
formulations at each concentration were collected from Weeks 1, 3, and 8
to assess the concentration of the test article. The samples were
collected from the middle of the container, while stirring, using a
syringe, and placed into 20 mL scintillation vials. Recoveries at all
levels were relatively low throughout the study period. Recoveries
ranged from 66.0-73.0% (Week 1), 59.5-84.7% (Week 3), and 25.1-99.5% (Week
8) in the treated groups.
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