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Administrative data

Description of key information

Two studies of repeated dose toxicity by oral route for Anthraquinone are available (as study summary) with these results:
NOAEL: 2 mg/kg bw/day (28-day study)
NOAEL: 1.36 mg/kg bw/day (90-day study)

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEL
1.36 mg/kg bw/day
Study duration:
subchronic
Species:
rat

Additional information

The toxicity of Anthraquinone was investigated in several studies using the oral (drinking water and feeding) and inhalation routes.

In a 28-day repeated dose toxicity study via oral route, the NOAEL value of 2 mg/kg bw/day and the LOAEL value 10 mg/kg bw/day were determined(Bayer AG, 1976, The Draft Assessment Report – Anthraquinone, Belgium, 2006).

In a 90-day repeated dose toxicity study via oral route,the NOAEL value 1.36 mg/kg bw/day and the LOAEL value 12.6 mg/kg bw/day were determined (Bayer AG, 1979, The Draft Assessment Report – Anthraquinone, Belgium, 2006).

In a 4 -month repeated dose toxicity study via inhalation route, the NOAEC was not determined, although the exposure to the concentration of 5.2 mg/m3 did not elicit any adverse effect in animals (Volodchenko , V.A. et al., 1970).

Justification for classification or non-classification

Based on the test results and according to the EC criteria for classification and labelling requirements for dangerous substances and mixtures the test substance Anthraquinone does not have to be classified for repeated dose toxicity.