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Registration Dossier
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EC number: 201-549-0 | CAS number: 84-65-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974-1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: tested in USA, only brief summary available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- 14 days study
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Anthraquinone
- EC Number:
- 201-549-0
- EC Name:
- Anthraquinone
- Cas Number:
- 84-65-1
- Molecular formula:
- C14H8O2
- IUPAC Name:
- 9,10-dihydroanthracene-9,10-dione
- Details on test material:
- A.Q. Rec. Dry, Batch No. 234/74
Gray powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand
- Sex:
- female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Applied in the form of an aqueous slurry - the test material could not be completely removed from the skin with tap water or other innocuous solvents.
- Doses:
- 300, 1000, 3000 mg/kg
- No. of animals per sex per dose:
- 1
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- no
- Clinical signs:
- other: No pharmacotoxic symptoms were noted
- Gross pathology:
- Necropsy examination did not reveal any gross pathologic alterations.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test material was non-irritating to the skin of albino rabbit.
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