Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974-1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: tested in USA, only brief summary available

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
14 days study
GLP compliance:
not specified
Test type:
fixed dose procedure
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
A.Q. Rec. Dry, Batch No. 234/74
Gray powder

Test animals

Species:
rabbit
Strain:
other: New Zealand
Sex:
female

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Applied in the form of an aqueous slurry - the test material could not be completely removed from the skin with tap water or other innocuous solvents.
Doses:
300, 1000, 3000 mg/kg
No. of animals per sex per dose:
1
Control animals:
not specified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Based on:
not specified
Mortality:
no
Clinical signs:
No pharmacotoxic symptoms were noted
Body weight:
see table above
Gross pathology:
Necropsy examination did not reveal any gross pathologic alterations.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The test material was non-irritating to the skin of albino rabbit.