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EC number: 215-252-9
CAS number: 1315-01-1
See section 7.8.1 (Toxicity to
Table 4. Number
of live pups and sex
5. Average body weight-Pups
6. Reproduction data
7. Fertility parameters
The OECD 421 Screening Test
can be used to provide initial information on possible effects on
reproduction and/or development, either at an early stage of assessing
the toxicological properties of chemicals, or on chemicals of concern.
It can also be used as part of a set of initial screening tests for
existing chemicals for which little or no toxicological information is
available, as a dose range finding study for more extensive
reproduction/developmental studies, or when otherwise considered
relevant. Males were dosed for a minimum of four weeks and up to and
including the day before scheduled kill (this includes a minimum of two
weeks prior to mating, during the mating period and, approximately, two
weeks post-mating). Females were dosed for at least 2 weeks prior to
mating, during mating and gestation up to the third day of lactation.
For the reproductive findings,
reference is made to Section7.8.1. For the developmental part of the
study, the number of pups, average weight of litter, average body weight
of pups on the day of parturition, 1st day after parturition and the 4th
day of lactation were insignificantly influenced by the test substance
treatment. A slightly lower average number of pups per mother
accompanied by lower weight of the litter was detected at the dose
levels of 300 and 1000 mg/kg/day but the numbers were not out of
historic control. Vice versa, the average weight of pups was higher in
treated groups against the control group. Development of pups was not
affected by the test substance treatment. Macroscopic abnormalities were
only sporadically detected at necropsy of pups and microscopical
evaluation of these findings did not reveal relevant pathological
effects. In conclusion, NOAEL for the Development of pups was 1000
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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