Registration Dossier
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EC number: 215-252-9 | CAS number: 1315-01-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
A 90- day repeated dose toxicity study in rats daily dosed with Tin sulfide at doses of 100, 300 and
1000 mg/kg bw per day resulted in a slight increase in food consumption, associated with slight increases
in body weight and serum glucose concentrations in females dosed at 1000 mg/kg, as well as slight
decreases in serum Na and Cl. Except for the above mentioned changes, Tin sulfide did not cause any
other changes. Therefore Tin sulfide was considered safe and well tolerated up to the dose of
1000 mg/kg bw/day. The NOAEL was defined at 1000 mg/kg and the NOEL at 300 mg/kg.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- High (Klimisch 1)
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
A key 90- day repeated dose toxicity study in rats daily dosed with Tin sulfide was available (Slais, 2010). Four groups of rats (male/female Wistar rats) were daily administered with the test item suspension in 0.5% Carboxymethylcellulose (CMC) orally by gavage for 90 days.Three treated groups were administered with doses of 100, 300 and 1000 mg/kg bw per day. Dosing resulted in a slight increase in food consumption, associated with slight increases in body weight and serum glucose concentrations in females dosed at 1000 mg/kg. These were however not considered as adverse effects. Slight dose dependent decreases in serum Na and Cl, varying within physiological range, were observed. Except for the above mentioned changes, Tin sulfide did not cause any negative effect on body weight, food consumption, ophthalmoscopy, hematology and clinical chemistry parameters and organ weights. Tin sulfide further did not cause any organ weight changes nor gross or histopathological changes in the liver, kidneys, gastrointestinal tract or other organs of survived animals indicative of a toxic effect. Under the test conditions used, 90 - day administration of the test item Tin sulfide to rats was safe and well tolerated up to the dose of 1000 mg/kg bw/day. The NOAEL was defined at 1000 mg/kg and the NOEL at 300 mg/kg.
Based on the similar structural and physicochemical properties of Tin disulfide (target chemical) and tin sulfide (source chemical), as well as the comparable and low toxicological profiles for acute toxicity, local tolerance and genetic toxicity, the results of the 90-day repeated dose toxicity study with Tin sulfide are considered valid as read-across to Tin disulfide. Therefore no new study has been conducted and current study is considered key study for repeated dose toxicity of Tin disulfide. Further argumentation is provided in a separate document on read-across argumentation under Section 13.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint: Key study with read across substance. Argumentation on the adequacy of read across between target and source chemical has been documented in a separate document (see Section 13).
Justification for classification or non-classification
No classification and labelling is needed for repeated dose toxicity for Tin disulfide according to EU labelling regulations Commission Directive 93/21/EEC and CLP regulation (No. 1272/2008 of 16 December 2008).
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