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EC number: 215-252-9
CAS number: 1315-01-1
Three healthy New
Zealand White rabbits (male), free from evidence of ocular irritation
and corneal abnormalities were dosed with tin disulfide. The test
article (0.1 mL equivalent (94.4 mg)) was placed into the conjunctival
sac of one eye of each rabbit. The contralateral eye served as a
control. The eyes were examined pretest and scored by the Draize
technique at 1, 24, 48 and 72 hours postdose.
There was no corneal opacity
or iritis noted at any observation period. Conjunctival irritation of
redness and or discharge, was noted in two out of three eyes, one eye
cleared by 24 hours and the other eye by 48 hours. The control eyes
appeared normal at all observation periods. There were no abnormal
physical signs noted during the observation period. One animal gained
body weight and the other two animals remained the same.
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