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EC number: 215-252-9
CAS number: 1315-01-1
1. Body Weight, Body Weight Changes and Pre-Terminal Deaths
Body weight (g)
Pre- terminal deaths (%)
(day 8 – Initial)
(day 15 – Initial)
An acute dermal toxicity
test was conducted with Wistar rats (male and female) to determine the
potential for Tin disulfide (CAS 1315-01-1) to produce toxicity from a
short term exposure via the dermal route. The test item at the dose of
2000 mg/kg body weight was made into a paste by adding sufficient volume
of Milli-Q water, transferred on to the cotton gauze (size: Males: 9 x 6
cm; Females: 8 x 5 cm of 6 ply) and applied on to the clipped
dorsolateral thoracic surface of the skin of the rats to cover about 10%
of body surface of the animal under adhesive tape wound around torso.
The test item contact period with the skin was for 24 hours. After the
24 hour contact period, the dressing was removed and the applied area
was washed and dried with a cotton hand towel. There were no clinical
signs of toxicity, local skin reaction or mortality. At the end of
observation period, all surviving animals were euthanized and subjected
to necropsy. There were no abnormalities detected at the necropsy. Based
on the present study results, the acute dermal LD50 of Tin disulfide >
2000 mg/kg body weight in male and female Wistar rats.
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