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EC number: 215-252-9
CAS number: 1315-01-1
Table 1. Test Atmosphere Particle Size
Distribution Data (Main Study)
Size Range (µm)
Total Mass/stage (mg)
Cumulative Mass (%)
In the sighting study, the mean achieved atmosphere
concentration was 5.06 mg/L, MMAD was 3.62 µm ± 2.12 GSD. Wet fur and
fur staining were commonly recorded on the day of exposure and several
days after exposure in both groups. These observations were considered
to be related to the restraint and exposure procedures and, in
isolation, were considered not to be of toxicological relevance. The
following significant clinical signs were recorded on the day of
exposure: laboured respiration and respiratory rate increase. In
addition, weak condition and respiratory rate increased were recorded in
animals on Day 1 or/and 2. All significant clinical signs ceased from
Day 3 of the observation period. Normal body weight
gain was recorded during whole observation period. No gross macroscopic
observations were apparent at necropsy.
In the main study,the mean achieved atmosphere
concentration was 5.02 mg/L. The MMAD (Mean Mass Aerodynamic Diameter)
was 3.91 µm ± 2.13 (GSD). Significant clinical signs were recorded on
the day of exposure including laboured respiration and respiratory rate
increase. All animals recovered by Day 2. Normal bodyweight gain was
recorded, with the exception of one female where a slight body weight
loss was recorded during the first three days of the observation period.
No gross macroscopic observations were apparent at necropsy.
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