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EC number: 215-252-9 | CAS number: 1315-01-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Both in vitro and in vivo studies were performed in a tiered testing approach, demonstrating that Tin disulfide
is not corrosive or irritating to skin and eye. The same approach was done for read-across substance
Tin sulfide, which also was negative for skin and eye corrosion and irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In vitro studies to predict skin corrosion and irritation of tin disulfide were performed by means of MatTek EpiDerm(TM) according to OECD 431 (Piehl, 2012a) and OECD 439 method (Piehl, 2012b). In the first study, mean tissue viability was 99.4% (3 min) and 96.7% (60 min); predicted corrosivity of tin disulfide was non-corrosive. In the second study, mean tissue viability was 101.2%, therefore predicted irritation potential was non-irritant. These studies, with negative outcome, were not enough for classification, therefore they were considered to be supportive. As a final step, a key in vivo study for skin irritation was performed in New Zealand White rabbits with tin disulfide by semi-occlusive dermal application according to OECD 404 method (Yasso, 2012). Erythema and edema were scored at 1, 24, 48 and 72 hours and on Day 7 following patch removal. At 1 hour post exposure, erythema was absent to very slight and edema was absent. At 24 hours erythema was very slight, edema was absent and shiny areas were observed in one animal. By 48 hours, erythema was absent to very slight and edema was absent with shiny areas and flaking skin observed. Erythema remained absent to very slight, edema was absent and flaking skin persisted at 72 hours. Both erythema and edema were absent by Day 7. No abnormal physical signs were observed.Two animals had net body weight gain by study termination, although one of the animals lost weight between 72 hours and Day 7. The remaining animal lost weight by study termination. The Modified Primary Irritation Index was 0.55. In conclusion, tin disulfide is not a Category 2 irritant according to CLP Regulation. Supporting information was also available from tin sulfide as read across substance. MatTek EpiDerm(TM) testing according to OECD 431 showed a mean tissue viability of 101.3% (3 min.) and 107.8% (60 min.), therefore predicted corrosivity of tin sulfide was non-corrosive (Piehl, 2010a). Dermal irritation potential tested in MatTek Epiderm(TM) according to OECD 439 showed a mean tissue viability of 101.5%, therefore predicted irritation potential of tin sulfide was non-irritant (Piehl, 2010b). Finally, in vivo testing for skin irritation in rabbits according to OECD method 404 demonstrated that there was no erythema or edema observed after 4 hours semi-occlusive application. Test article stained the dose sites at all observation periods, but there were no abnormal physical signs and body weights were normal. Tin disulfide and Tin sulfide showed a comparable tolerance profile for this endpoint.
An in vitro study to predict eye damage and irritation of tin disulfide was performed by means of HETCAM test according to Invittox method No. 47 (Cerven, 2012). The chorioallantoic membrane (CAM) of White Leghorn eggs, incubated for 10 days, was dosed with 0.3 mL test substance at 10% (w/v) in olive oil, leading to an irritation score (IS) of 0. Based on a threshold concentration of >10% and the IS 10% of 0, the irritating potential of the test article, was determined as none to slight. This study, with negative outcome, was not enough for classification, therefore it was considered to be supportive. Next, a key in vivo study according to Draize method was performed with tin disulfide in three New Zealand White rabbits (Blair, 2012). The test article (0.1 mL equivalent (94.4 mg)) was placed into the conjunctival sac of one eye of each rabbit. The eyes were examined pretest and scored by the Draize technique at 1, 24, 48 and 72 hours postdose. There was no corneal opacity or iritis noted at any observation period. Conjunctival irritation of redness and or discharge, was noted in two out of three eyes, one eye cleared by 24 hours and the other eye by 48 hours. The control eyes appeared normal at all observation periods. There were no abnormal physical signs noted during the observation period. One animal gained body weight and the other two animals remained the same. Supporting information was also available from tin sulfide as read across substance. HETCAM testing according to Invittox showed an irritation score of 0 (Cerven, 2010), whereas in vivo testing for eye irritation in rabbits according to OECD method 405 demonstrated that there was no eye irritation (Blair, 2010). Tin disulfide and Tin sulfide showed a comparable tolerance profile for this endpoint.
Justification
for selection of skin irritation / corrosion endpoint:
Key
in vivo study with reference substance confirming absence of irritation
Justification
for selection of eye irritation endpoint:
Key
in vivo study with reference substance confirming absence of irritation
Justification for classification or non-classification
No classification and labelling is needed for skin and eye corrosion or irritation of tin disulfide according to EU labelling regulations Commission Directive 93/21/EEC and CLP regulation (No. 1272/2008 of 16 December 2008).
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