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EC number: 215-252-9
CAS number: 1315-01-1
For tin disulfide an algal study is
available. this study demonstrated that the tin sulfide has no toxic
effects at the limit of water solubility, i.e., at 0.67 µg/L. The other
aquatic endpoints were covered using data from tin sulfide which has an
almost identical water solubility, i.e., 0.6 µg/L. The algal study was
used as bridging study since the WHO concluded in their report that
algae are the most sensitive group. Furthermore, the WHO concluded that
Sn II is more toxic than Sn IV. Hence, read across from tin sulfide (Sn
II) to tin disulfide (Sn IV) was considered justified.
The acute toxicity of tin sulfide to
Gobiocypris rarus was conducted in accordance with OECD Guideline 203.
Under valid static test conditions the 96 h-LL50 is greater than nominal
tested concentration of 100 mg/L WAFs (measured concentration 0.014
The 13–day chronic toxicity of tin
sulfide to early life stage of Brachydanio rerio was studied
under semi-static conditions. Totally 60 embryos were exposed to
measured tin sulfide concentrations up to 33 µg/L, which is the highest
soluble fraction from a 100 mg/L (nominal) tin sulfide concentration.
The test system was maintained at 23.9 to 25.8 ºC and a pH of 6.91 to
7.67. The 13–day EC50value, based on mortality,
was >33 µg a.i./L. The sublethal effects included were hatching, weight
and length of animals. The most sensitive end point was weight, the NOEC
being 7 µg/L (equals to 12.5% of filtrate from soluble fraction of 100
The 21-day-chronic toxicity of tin sulfide
to Daphnia magnawas studied under semistatic conditions. The
sublethal effects included were reproduction output, reduction of parent
growth and intrinsic rate. The most sensitive end point was reduction of
reproduction output, the NOEC was 3 µg/L (equals 12.5 % of maximum
soluble fration of nominal 20 mg/L).
EC50 (all endpoints): higher than 11.3 µg/L
(equals to 100 % of maximum soluble fraction of nominal 20 mg/L).
In a 72-hour toxicity study, the
cultures ofPseudokirchneriella subcapitatawere exposed to Tin
sulfide at a measured concentration of 34 µg a.i./L, which was the
soluble fraction from a nominal 100 mg/L tin sulfide concentration,
under static conditions in accordance with the OECD 201 Guideline. No
effects were observed, neither on growth rate, biomass reduction or
changes in cell morphology.
In a test on respiration inhibition of
activated sludge according to OECD 209, no effects were observed at a
nominal concentration of 11 µg/L, which was prepared from a saturated
solution in deionized water from nominal 100 mg/L tin sulfide. In an
additional experiment, no effects were observed at concentrations up to
1000 mg/L directly weighed in.
Based on this information and the read
across information it can be concluded that tin disulfide results in no
acute and chronic effects up to the limit of water solubility, i.e.,
Based on the lack of acute or chronic
effects at concentrations at or below the water solubility of tin
disulfide no classification is needed according to EU Regulation
1272/2008 and 67/548 EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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