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EC number: 215-252-9
CAS number: 1315-01-1
Table 2. Dermal and Systemic observations
Time after patch removal
Sum of Mean Scores =
Modified Primary Irritation Index (PII)
= Sum of Mean Scores/3 =
f= flaking skin
s= shiny areas
Three healthy New Zealand White rabbits (males)
were dosed dermally with Tin disulfide. The test article (0.56 g) was
applied dermally to one intact site per rabbit and wrapped with a piece
of porous dressing (semi-occlusive) large enough to cover all dose sites
with at least 5 cm square to spare on all sides of the gauze patch. The
test article was kept in contact with the skin for 4 hours at which time
the wrappings were removed. Erythema and edema were scored at 1, 24, 48
and 72 hours and on Day 7 following patch removal. The skin was also
evaluated for ulceration and necrosis or any evidence of tissue
destruction at these time periods. Animals were observed for
toxicological and pharmacological effects at each dermal observation
period and observed for mortality daily. Body weights were recorded
pretest, at 72 hours and at termination. At 1 hour post exposure,
erythema was absent to very slight and edema was absent. At 24 hours
erythema was very slight, edema was absent and shiny areas were observed
on one animal. By 48 hours, erythema was absent to very slight and edema
was absent with shiny areas and flaking skin observed. Erythema remained
absent to very slight, edema was absent and flaking skin persisted at 72
hours. Both erythema and edema were absent by Day 7. No abnormal
physical signs were observed. Two animals had net body weight
gain by study termination, although one of the animals lost weight
between 72 hours and Day 7. The remaining animal lost weight by study
termination. The Modified Primary Irritation Index was 0.55. Tin
disulfide (CAS 1315-01-1; EINECS: 215- 252-9), Tin disulphide; Trade
name: Tribotecc® - SNS2 Grade A, Batch# E 10320 is not a Category 2
irritant according to Regulation (EC) No. 1272/2008, Section 220.127.116.11.
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Tällä verkkosivustolla käytetään evästeitä parhaan mahdollisen käyttäjäkokemuksen varmistamiseksi.
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