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EC number: 215-252-9 | CAS number: 1315-01-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Tin disulfide had no sensitising effect in the murine local lymph node assay according to OECD guideline 429. This was confirmed by a study on the read-across substance tin sulfide.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A key Local Lymph Node Assay (LLNA) with Tin disulfide was conducted to study potential contact sensitisation by measuring lymphocyte proliferative response from auricular lymph nodes following topical application of the test item to the female CBA/Ca mouse ear (Sulaiman, 2012). After a screening phase, five female mice/group received the vehicle (DMSO) or 30% α-hexylcinnamaldehyde (HCA: positive control in DMSO) or 5, 10, 15, 30 and 50% w/v of Tin disulfide in DMSO on days 1 to 3. On day 6, a volume of 250 µL (20 µCi) of 3H-TdR in PBS was administered to each mouse via the lateral tail vein, and uptake into the auricular lymph nodes draining the site of test item application was measured five hours post administration. Proper conduct of the LLNA was confirmed via a positive response using 30% HCA, which elicited proliferation with a Stimulation Index (SI) value of 6.10, in comparison to vehicle-treated mice.The test item did not elicit erythema, no clinical signs and no effect on body weight gain at the tested concentrations. The test item at dose concentrations of 5, 10, 15, 30 and 50% w/v elicited proliferative response with SI of 0.42, 0.41, 1.98, 2.35 and 2.87, respectively in comparison with the vehicle-treated mice. Tin disulfide therefore did not demonstrate dermal sensitization potential in the mouse LLNA, as the lymph nodes draining the area of topical application did not elicit a proliferative response greater than the 3X threshold.
A supporting Local Lymph Node Assay (LLNA) with Tin sulfide as read across substance (Prochazkova, 2010) was also negative for skin sensitisation. Tin disulfide and Tin sulfide showed a comparable toxicological profile for this endpoint.
Short description of key information: Both a key Local Lymph Node Assay (LLNA) with Tin disulfide and a supporting LLNA with Tin sulfide were negative, indicating absence of potential for skin sensitisation.
Justification for selection of skin sensitisation endpoint: Key in vivo study with reference substance confirming absence of sensitisation.
Justification for classification or non-classification
No classification and labelling is needed for skin sensitisation for Tin disulfide according to EU labelling regulations Commission Directive 93/21/EEC and CLP regulation (No. 1272/2008 of 16 December 2008).
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