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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Method and results rudimentarily reported

Data source

Reference
Reference Type:
publication
Title:
The metabolism of the monochloronitrobenzenes in the Rabbit
Author:
Bray HG, James SP, Thorpe WV
Year:
1956
Bibliographic source:
Biochem J 64, 38-44 (1956)

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
Rabbits were dosed with 100 mg m-chloroaniline/kg bw and the metabolites determined in the urine.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
other: liquid
Details on test material:
no data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Duration and frequency of treatment / exposure:
pobably single application
Doses / concentrations
Remarks:
Doses / Concentrations:
100 mg/kg bw
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:
Metabolites of monochlorobenzene derivatives were analyzed in the urine of rabbits. for most purposes urines were collected each 24 hours, until metabolites were no longer excreted (usually 48 hrs.).

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
After dosage with m-chloroaniline, the metabolites 2-amino-4-chlorophenol and 4-amino-2-chlorophenol was detected in the urine hydrolyzed with sulfuric acid.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
Executive summary:

Rabbits were dosed with 100 mg m-chloroaniline/kg bw and the metabolites determined in the urine. After dosage with m-chloroaniline, the metabolites 2-amino-4-chlorophenol and 4-amino-2-chlorophenol was detected in the urine hydrolyzed with sulfuric acid.