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EC number: 203-581-0 | CAS number: 108-42-9
m-chloroaniline did not significantly increase the incidence of abnormal sperm heads.
Groups of 5 (male CBA x female BALB/c) F1 male mice; 10-12 weeks old; received 5 daily i.p. injections of the test substance (25, 50, 100 or 200 mg/kg bw) or vehicle alone (5 ml/kg bw/day). Positive controls (20 mg/kg/day cyclophosphamide monohydrate) are included in the study. 5 weeks after the last dose the mice are killed and sprem from the cauda epididymidis are suspended in saline. Smears of sperm from each animal are dried and stained with Eosin Y. Sperm heads are classified as of normal or abnormal morphology. Differences in the incidence of abnormal sprem between the groups are compared using the Wilcoxson Rank Sum Test.
As a result, m-chloroaniline did not significantly increase the incidence of abnormal sperm heads in the highest applied dose of 200 mg/kg bw (1/2 LD50).
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