Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: Case report
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Erythrocytic inclusion bodies in the blood of chemical workers
Author:
Hughes JP, Treon JF
Year:
1954
Bibliographic source:
Arch Ind Hyg Occup Med 10, 192-202 (1954)

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
acute toxicity: dermal
Principles of method if other than guideline:
A chemical operator spilled a small amount of m-chloroaniline on his trousers.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
no data

Method

Subjects:
49-year old white chemical operator
Route of exposure:
dermal
Reason of exposure:
unintentional, occupational
Exposure assessment:
not specified

Results and discussion

Clinical signs:
About one hour later he became weak and lightheaded and was told by a fellow workman that his lips were blue. Four hours after the exposure, when cyanosis was most marked, 5% of the erythrocytes contained Heinz bodies. On the next day, after hospitalisation overnight and the administration of oxygen, slight cyanosis persisted. The percentage of red cells with Heinz bodies was now 18; on the third day it was 28, and on the seventh day 20. There was no anemia. The man returned to work on the fourth day after the exposure.

Any other information on results incl. tables

A 49-year old white chemical operator, in charging an autoclave spilled a small amount of m-chloroaniline on his trousers. About one hour later he became weak and lightheaded and was told by a fellow workman that his lips were blue. Four hours after the exposure, when cyanosis was most marked, 5% of the erythrocytes contained Heinz bodies. On the next day, after hospitalisation overnight and the administration of oxygen, slight cyanosis persisted. The percentage of red cells with Heinz bodies was now 18; on the third day it was 28, and on the seventh day 20. There was no anemia. The man returned to work on the fourth day after the exposure.

Applicant's summary and conclusion

Executive summary:

A 49-year old white chemical operator, in charging an autoclave spilled a small amount of m-chloroaniline on his trousers. About one hour later he became weak and lightheaded and was told by a fellow workman that his lips were blue. Four hours after the exposure, when cyanosis was most marked, 5% of the erythrocytes contained Heinz bodies. On the next day, after hospitalisation overnight and the administration of oxygen, slight cyanosis persisted. The percentage of red cells with Heinz bodies was now 18; on the third day it was 28, and on the seventh day 20. There was no anemia. The man returned to work on the fourth day after the exposure.