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Toxicological information

Epidemiological data

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Administrative data

Endpoint:
epidemiological data
Type of information:
other: epidemiological data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Erythrocytic inclusion bodies in the blood of chemical workers
Author:
Hughes JP, Treon JF
Year:
1954
Bibliographic source:
Arch Ind Hyg Occup Med 10, 192-202 (1954)

Materials and methods

Study type:
case control study (retrospective)
Endpoint addressed:
repeated dose toxicity: dermal
Principles of method if other than guideline:
36 male workmen occupied in the 'Aniline building' of a chemical plant were questioned in an especial thourough way as to the occurence of cyanosis, weakness, and dizziness and of symptoms referable to skin and respiratory systems. The analysis of air samples obtained in this plant revealed monomethylaniline, aniline and m-chloroaniline (0.13 and 0.29 ppm) measured on different locations.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
no data

Method

Details on study design:
36 male workmen occupied in the 'Aniline building' of a chemical plant were questioned in an especial thourough way as to the occurence of cyanosis, weakness, and dizziness and of symptoms referable to skin and respiratory systems. The analysis of air samples obtained in this plant revealed monomethylaniline, aniline and m-chloroaniline (0.13 and 0.29 ppm) measured on different locations. The mean exposure period was 41.2 month. The mean age of the group of 36 was 28.2 years.
Exposure assessment:
measured

Results and discussion

Results:
Nine of the 36 workers gave a history of 'blue lip', i.e. methemoglobinemia, at least one during work. The clinical investigation and routine blood and urine diagnosis did not revealed no significant abnormalities. Of the 36 workmen, 28 had 1% or less of Heinz bodies in red blood cells, in no case was there more than 4%.
Confounding factors:
Aniline and monomethylaniline

Applicant's summary and conclusion

Executive summary:

36 male workmen occupied in the 'Aniline building' of a chemical plant were questioned in an especial thourough way as to the occurence of cyanosis, weakness, and dizziness and of symptoms referable to skin and respiratory systems. The analysis of air samples obtained in this plant revealed monomethylaniline, aniline and m-chloroaniline (0.13 and 0.29 ppm) measured on different locations.

Nine of the 36 workers gave a history of 'blue lip', i.e. methemoglobinemia, at least one during work. The clinical investigation and routine blood and urine diagnosis did not revealed no significant abnormalities. Of the 36 workmen, 28 had 1% or less of Heinz bodies in red blood cells, in no case was there more than 4%.