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EC number: 203-581-0 | CAS number: 108-42-9
m-chloroaniline (1 to 2,000 μg/plate) was tested with a preincubation protocol at two laboratories for mutagenicity in Salmonella typhimurium strains TA97, TA98, TA100, TA1535, and TA1537, with and without Aroclor 1254-induced male Sprague-Dawley rat or Syrian hamster liver S9; no mutagenic activity was observed.
m-Chloroaniline was evaluated with the S. typhimurium tester strains TA97, TA98, TA100, TA1535, and TA1537 either in buffer or S9 mix (metabolic activation enzymes and cofactors from Aroclor 1254-induced male Sprague-Dawley rat or Syrian hamster liver) for 20 minutes at 37°C. Top agar supplemented with L-histidine and d-biotin was added, and the contents of the tubes were mixed and poured onto the surfaces of minimal glucose agar plates. Histidine-independent mutant colonies arising on these plates were counted following incubation for 2 days at 37°C.
Each trial consisted of triplicate plates of concurrent positive and negative controls and of at least five doses of m-chloroaniline. The high dose was limited by toxicity.
m-chloroanilinewas negative in Salmonella typhimurium strains TA97, TA98, TA100, TA1535, and TA1537, with and without metabolic activation.
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