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Description of key information

Metabolites of m-chloroaniline  in the urine of rats and rabbits after oral application and in the blood of dogs after intravenous injection were determined. Additionally the elimination time of m-chloroanilinefrom the body was investigated.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

In rats and rabbits the majority of ingested m-chloroaniline was eliminated within 24 hours. In dogs the majority of m-chloroaniline was eliminated from the blood within a few hours.

The leading metabolic reaction in rats is the ring hydroxylation of m-chloroaniline. The main metabolites were derivatives of 4-amino-2-chlorophenol and to a lesser part of 2-amino-4-chlorophenol. In rabbits after dosage with m-chloroaniline, the metabolites 4-amino-2-chlorophenol and 2 -amino-4 -chlorophenol (the same as in rats) were detected in the urine hydrolyzed with sulfuric acid.

In dogs m-chloronitrosobenzene and N-hydroxy-m-chloroaniline were detected as metabolites in the blood 2 hours after intravenous injection of m-chloroaniline.