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Physical & Chemical properties

Dissociation constant

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Administrative data

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from peer-reviewed handbook or collection of data.

Data source

Reference
Reference Type:
review article or handbook
Title:
Dissociation Constants of Organic Bases in Aqueous Solution
Author:
Perrin, D. D.
Year:
1965
Bibliographic source:
International Union of Pure and Applied Chemistry, UK

Materials and methods

GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
- Purity not reported
- Empirical formula: C6H6ClN
- Molecular mass: 127.58 g/mole

Results and discussion

Any other information on results incl. tables

Results:

 pK

 Temperature

[°C]

 Remarks  Methods  Reference
3.46   25  C = 0.001, I = 0.02

O 5 

 Bryson, A., J. Am. Chem. Soc., 82, 4858 (1960)
 3.67  25

 c = 4x10-5, pK

of aniline taken as 4.57

 O 5  Roberts, J. D et al.,  J. Am. Chem. Soc., 72, 408, (1950)
3.52   25  c = 4x 10-4

O 5 

with activity

corrections

 Biggs, A. I. et al., J. Chem. Soc., 1961, 388
3.60   25    

O 5 

with activity

corrections

 
  Biggs, A. I. et al., J. Chem. Soc., 1961, 2572
 3.52  25      
 3.46  30      
 3.39 35       
 3.33  40      
 3.33  25

 Few exp. details

O 2   Kilpatrick, M. and Arenberg, C. A., J. Chem. Soc., 75, 3812 (1953)
 5.52  25

 "Mixed" constant,

I not stated

O 5   Vandenbelt, J. M. et al., Anal. Chem., 26, 726 (1954)
 3.4  25   

"Mixed" constant,

I not stated

E3bg   
 3.46  25

 I = 0.02 Other

measurement: a, b

 Partition  Williams, G. and Soper, F. G., J. Chem. Soc. 1930, 2469

c = concentration in mole/L

I = ½Σcizi2 = ionic strenght

O 5 =  Light absorption measurements combined with electrometric measurements

O 2 = Colorimetric determination with an indicator of known pK

E3bg = Measurements of pH changes during titrations using glass electrodes

Other measurement:

a = Brönsted, J. N. et al., Z. Physik. Chem. A169, 361 (1934)

b = Mason, S. F., J. Chem. Soc. 1954, 2071

Applicant's summary and conclusion

Conclusions:
The dissociation constant of 3-chloraniline was measured as a pK of 3.52 at 25 °C.
Executive summary:

The dissociation constant of 3-chloraniline was measured as a pK of 3.52 at 25 °C.