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EC number: 204-000-3
CAS number: 112-72-1
Significant technical difficulties were encountered during method
development for a recent study of adsorption/desorption (OECD 106,
Wildlife, 2015) of the structurally analogous alcohol, decan-1-ol (CAS
112-30-1), using natural standard soils, in that it was not possible to
detect sufficient substance and establish equilibrium in non-sterilised
soil samples. During method development in preparation for this study,
the laboratory reported that after equilibration with soils for
15-minute to 24-hour periods, decan-1-ol dosed into the test vessels was
partly or completely transformed into a more polar product, which was
clearly distinguishable from the starting material as clear and well
separated peaks in the chromatograms. The rate of transformation depends
on the soil type. Only after a very short (5-minute) equilibration the
parent material remained intact (personal communication, 8 January 2015
from Wildlife International laboratory). Half-lives were not explicitly
derived, but chromatograms presented would indicate the half-life of
decan-1-ol in the soil test samples was approximately 30 min - 1 hour
(silt loam soil); 1 - 2 hours (loamy sand), and 15 - 30 minutes (clay
loam). Following sterilisation of the soil samples by autoclaving, the
substance remained adequately stable for a 2-hour period, therefore the
instability can be attributed to biodegradation of the substance by soil
microbiota. The polar degradation product is most likely the
corresponding carboxylic acid, though it was not definitively
identified. The chromatograms show that decan-1-ol was effectively fully
removed in all four soil types by the 24 h time point (in the case of 2
of the soil types, within 2 hours). Similar degradation can be expected
accordance with Column 2 of REACH Annex IX, the full soil simulation
test (required in Section 220.127.116.11) does not need to be conducted as the
substance is readily biodegradable. Furthermore a close structural
analogue, decan-1-ol (CAS 112-30-1), has been shown to be very rapidly
degraded in non-sterilised standard soils as part of method development
for the soil adsorption study.
of trends in the Category of C6-24 linear and essentially-linear
available regarding persistence in soil are limited. A commercial
multi-constituent substance (CAS 68155-00-0 (C14-18 and C16-18
unsaturated) and CAS 68002-94-8 (C16-18 and C18 unsaturated)) was found
to be readily biodegradable in a reliable OECD 301D study using a
non-standard inoculum; garden soil microorganisms (Borner, 1999).
and reliable study of adsorption and desorption using the batch
equilibrium method (in compliance with OECD 106 and GLP) has been
conducted with decan-1-ol (CAS 112-30-1).
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