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EC number: 204-000-3
CAS number: 112-72-1
of revertants per plate (mean of 3 plates) for Test 1
control with DMSO
Table 2: Number
of revertants per plate (mean of 3 plates) for Test 2
In the bacterial mutagenicity study, the ability of tetradecan-1 -ol to
induce mutations in bacteria was tested.
In test I, 50, 150, 500, 1500, and 5000 µg/plate of test material were
applied to S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 1538
without metabolic activation. In test II, the same concentrations of the
test material were applied to
S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 1538, in the
presence and absence of metabolic activation system. The exposure
duration was approximately 48 hours.
After incubation, numbers of revertant colonies were counted. For a
substance to be considered positive in this test system, it should have
induced a dose-related and statistically significant increase in
mutation rate in one or more strains of bacteria in the presence and/or
absence of metabolic activation in both experiments at sub-toxic dose
levels. For a negative result the numbers of induced revertants should
be less than two fold compared to controls.
The study reports tetradecan-1 -ol to be not mutagenic to S. typhimurium
when tested up to limit concentration. The study was conducted according
to an appropriate OECD test guideline, with acceptable restriction. The
restriction was that no cross linking strain was used, so does not
comply with current guidelines. It was compliant with GLP.
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