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EC number: 204-000-3
CAS number: 112-72-1
Table 1: Number of animals dead
within the 14 day observation period.
Mortality (# dead/total)
Time range of deaths (day)
9 and 11
animals were from the group with skin prepared with abrasion.
In the acute dermal toxicity study, 2, 4 and 8 g/kg of test material was
applied to the flanks of 2 male and 2 female rabbits per dose, kept in
contact to the skin under occlusive dressing for 24 hours. The
experiement was performed on intact and abrated skin. Body weight
changes and clinical signs of toxicity were noted regularly. Necropsy
was performed at the end of the 14 -day study period.
100% of the animals with abraded skin died between 8 and 10 days of the
exposure period. The animals with intact skin survived. At twenty-four
hours following test application, all animals showed slight to moderate
erythema, desquamation, wrinkling and dryness of the skin at the
treatment site. In all surviving animals, desquamation and wrinkling of
the skin occurred and persisted in varying degrees throughout the 14
-day study period. At the highest dosage level (8 g/kg body weight, two
of the surviving animals showed signs of weakness, emaciation and
pallor; however all appeared systematically normal within 96 hours
following exposure. Final body weight records of the surviving animals
at termination, showed a slight loss in one animal, a constant weight in
one animal and gains within expected limits in the eight remaining
animals. At necropsy, there was one animal with slight accumulation of
clear viscous fluid within the peritoneal cavity and crazing over cortex
of both kidneys. Eight animals showed no signs of gross systemic
An LD50 value of 8000 mg/kg bw was reported. The study was well
documented and meets generally accepted scientific principles, but was
not conducted in compliance with GLP.
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