Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-000-3
CAS number: 112-72-1
Table 1. Summary of immortalities.
The Authors of the report remarked: "Given
the likely influence of particulate test substance on the Daphnia, this
result should be used with caution."
Short-term toxicity to invertebrates: 48 h EC50: 3.2 mg/l (nominal
concentration) for the effects of the test substance on mobility of
Daphnia magna, i.e. >LoS (guideline OECD 202).
The effects seen need to be treated with caution because of the
formation of droplets in most of the test concentrations. However in
the range of the limit of solubility (1.9 mg/l) only 10% mortalities
were observed, therefore it may be said that tetradecanol is not
toxic at its limit of solubility.
This represents the lowest experimental value available for this
endpoint for tetradecanol.
A reliable short-term toxicity to invertebrates QSAR prediction has
determined the EC50 value to be 0.18 mg/l (Fisk et al.,
2009). This value is closer to the limit of water solubility of C14
than the experimental data value.
Discussion of trends in the Category of C6-24 linear and
essentially-linear aliphatic alcohols:
The data presented in the table below show the toxicity of
the linear LCAAs to increase from an EC50 of 200 mg/L
for C6 to 0.77 mg/L for C12. Effects have also been observed in
tests with C13 and C14 LCAAs but at concentrations that exceeded
the solubility of the alcohols. Although not explicitly identified
in the test reports, physical effects (rather than true toxicity)
cannot therefore be excluded from the interpretation of the
results for these two LCAAs. In the Unilever (1994) study with C14
the authors have recorded that the test substance adhered to the
daphnids at concentrations higher than the water solubility of
1-tetradecanol. This indicates that physical fouling is likely to
have caused the effects seen at the EC50 value of
The lowest reliable short-term EC/LC50 values
for invertebrates exposed to linear LCAAs are presented in the
Table: Key studies for invertebrate short-term toxicity
studies on single carbon chain length linear LCAAs.
Water solubility (mg/L)
5900 at 20°C
24 h EC50
Bringmann and Kuhn, 1982
1300 at 20°C
550 at 25°C
130 at 20°C
Nitocra spinipes (brackish)
96 h EC50
Bengtsson, Renberg, and Tarkpea, 1984
40 mg/L at 20°C
N. spinipes (brackish)
Decene, hydroformylation products
Supporting.hydroformylation product (=C11)
48 h LC50
Burgess and Forbis, 1983b
8.0 at 20°C
96 h LC50
1.9 at 20°C
48 h EC50
Laboratory of Pharmacology and Toxicology, 1997
0.38 at 20°C
EC50 (duration unknown)
0.19 at 25°C
1>LoS: LC50 observed
was greater than the limit of solubility (n) based on nominal
concentrations, (m) based on measured concentrations.
SUPPORTING denotes that the substance is not for registration but
the data are used to support the category
The data presented in the table below show the
multi-constituent substances containing LCAAs with carbon numbers
in the ranges of C7-9 to C12-15 to exert short-term toxicity at
concentrations of between 0.23 and 30 mg/L. At these
concentrations it is likely that all constituents will have been
fully dissolved. The short-term EC50 of the C14-15
LCAAs to aquatic invertebrate was determined to be above the limit
of solubility of the substance.
For the C12-14 and C12-18 multi-constituent substances there
was evidence of toxic effects in tests conducted on test media
prepared as water-accommodated fractions at loading rates that
exceeded the solubility of some constituents. For the C16-18
substance there was evidence of effects in test media that could
have contained undissolved test material. The possibility of
physical effects (rather than true toxicity) contributing to the
observed effects were not discussed in the test report but cannot
The lowest reliable short-term EC/LC50 values
for invertebrates exposed to multi-constituent LCAAs are presented
in the following table.
Table: Invertebrate short-term toxicity studies on mixed
carbon chain length (multi-constituent) LCAAs (species are
freshwater unless noted otherwise).
510 mg/L at a loading rate of 1000 mg/L (estimated)
Fraunhofer Institute, 2005a
Mixture of 68527-05-9 and 70955-11-2-
Mixture of hexane and octene hydroformylation products
i.e. alcohols, C7-9SUPPORTING
Burgess and Forbis, 1983c
Nonanol, branched and linear
Read-across from C9
Alcohols, C9-11- branched and linear
Also valid for Alcohols, C9-11 CAS 66455-17-2
44 at a loading rate of 1000 mg/L. (estimated)
Shell Research Limited, 1983
Also valid for Alcohols, C9-11 CAS 66455-17-2
Crangon crangon (marine)
Huntingdon Life Sciences Ltd. 1991a.
Mixture of 68516-18-7, 68527-05-9 and 70955-11-2-
Mixture of octane and decene hydroformylation products
Burgess and Forbis, 1983d
Decanol, branched and linear
Read-across from C10
26.17 at 20°C
Undecanol, branched and linear
Reaction mass of 2-methyldecan-1-ol and 2-propyloctan-1-ol and 2-ethylnonan-1-ol and 2-butylheptan-1-ol
Read-across from C11
6.3 at 25°C
Alcohols, C12-13-branched and linear
2.4 at 25oC
OECD 202 WAF
48 h EL50
C. crangon (marine)
>10 (n) (>LoS)
Huntingdon Life Sciences Ltd. 1991b.
2.9-3.1 at 20°C
Alcohols, C 12-14
4.6 predicted at 1000 mg/L loading rate
EU 92/69/EWG WAF
63 (n) (>LoS)
Alcohols, C12-15-branched and linear
0.80 at 20°C
Alcohols, C 12-18
1.7 predicted at 100 mg/L loading rate
40 (n) (>LoS)
Alcohols, C 16-18 and 18 Unsaturated
0.044 predicted at 1000 mg/L loading rate
EU Guideline 92/69/EWG
70 (n) (>LoS)
Henkel KGaA. 1995.
1Compositional Types are described in section 1.4.7 of
the category report.
2WAF denotes test medium was a water-accommodated
was greater than the limit of solubility of at least some
constituents of the substance. (n) based
on nominal concentrations, (m) based on measured concentrations.
n/a denotes not applicable
The data for nonanol, branched and linear, decanol branched
and linear, decanol branched and undecanol branched and reaction
mass of 2-methyldecan-1-ol and 2-propyloctan-1-ol and
2-ethylnonan-1-ol and 2-butylheptan-1-ol alcohols have been
read-across from their linear LCAAs counterparts (C9, C10 and C11)
since they are essentially linear LCAAs.
The measured data do not permit a definite toxicity cut-off to
be identified for the single carbon number LCAAs or the
multi-constituent substances. This is because the potential for
physical effects to contribute to the results obtained for the C13
and 14 single carbon number alcohols, and the multi-constituent
substances containing constituents with carbon numbers that are all
>C12, cannot be excluded. However, it is reasonable to conclude from
the data that are presented that it is unlikely that linear LCAAs
with carbon numbers >C13 and multi-constituent LCAAs with carbon
numbers all >C13 would be toxic.
Bengtsson, B., Renberg, L., and Tarkpea, M. (1984). Molecular
structure and aquatic toxicity-An example with C1-C13 aliphatic
alcohols. Chemosphere 13(5/6):613-622.
Bringmann, V. and Kuhn, R.1982. Results of toxic action
of water pollutants on Daphnia magna Straus tested by an improved
standardized procedure. Z. Wasser Abwasser Forsch. 15(1):1-6.
Burgess, D. and Forbis, A.D. 1983b. Acute toxicity of oxo alcohol
1100 to Daphnia magna. Static acute bioassay report 30851.
Burgess, D. and Forbis, A.D. 1983d. Acute toxicity of oxo alcohol
7911 to Daphnia magna. Static acute bioassay report 30848.
Burgess, D. and Forbis, A.D. 1983c. Acute toxicity of oxo alcohol
7900 to Daphnia magna. Static acute bioassay report 30845.
Fraunhofer Institute, 2005a, Daphnia, acute
immobilization, Linevol 79. Study SDA-04/4-20, Fraunhofer Institute.
Henkel, 1998a. Henkel Report No. R9800103.
Henkel,1998b. Henkel KGaA Report No. R9800104.
Henkel KGaA., 1995. Report No. 9400262. May 1995.
Huntingdon Life Sciences Ltd.(HLS).1991a. Report No.
Huntingdon Life Sciences Ltd.(HLS).1991b. Report No.
Laboratory of Pharmacology and Toxicology. 1997. Examination
of 1-Dodecanol in an acute immobilization test in Daphnia magna. LPT
Report No. 10762/97.
Shell, 2000a. Shell. RTS Report No. CT.00.47050.
Shell, 2001a. Shell. RTS Report No. OG.01.49011.
Shell Research Limited, 1983. Toxicity tests with Daphnia magna:
Acute toxicity of eight test materials to a newly-introduced strain
of D. magna in reconstituted fresh water. Shell Research Limited,
Sittingbourne Research Centre. SBGR.83.100.
TNO Nutrition and Food Research Institute. 2000b. Static acute
toxicity test with compound 33A abd the crustacean species Daphnia
magna. TNO report V98.1320.
Unilever, 1995. Acute toxicity of 1-tetradecanol to Daphnia magna.
Unilever. Study AT/ALC/BK4.
Unilever, 2010. The Acute toxicity of 1-tetradecanol to Daphnia
magna. Testing laboratory: Unilever Port Sunlight Research
Laboratory, Quarry Road East, Bebington, Wirral Merseyside, L63 3JW,
UK. Owner Company: Unilever. Company study no.: AT/ACL/BK4. Report
date: 2010-08-01 (2010 study report summarising a 1994 study).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again