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EC number: 204-000-3
CAS number: 112-72-1
The extra glucuronide excreted as % of dose (average of 3 rabbits, 2 rabbits for *) was as follows:
n-hexanol 10.3%; n-heptanol 5.3%; n-octanol 9.5%; n-nonanol 4.1%; n-decanol* 3.5%; n-octadecanol* 7.6%. It was reported that absorpton of
n-decanol and n-octadecanol was incomplete and irregular and the alcohol could be isolated in quantity from the faeces.
In addition in the case of n-decanol extra
glucuronic acid appeared in the urine on the second day after dosing
(whereas in most cases the excretion of extra glucuronic acid after
dosing was complete within 24 hours.
No further information on other biotransformation pathways of these alcohols was provided.
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