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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2009-10-02
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Remarks:
Test procedure in accordance with national standard methods (ASTM) without GLP.
Qualifier:
according to
Guideline:
other: ASTM E 1148
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Key result
Water solubility:
1.3 mg/L
Temp.:
23 °C
pH:
5.5
Remarks on result:
other: Standard Deviation for these Data : +/- 0.6 mg/L

Measurement

(triple determination)

Results: 1.5 mg/L / 1.0 mg/L / Not Detected

Mean Concentration in Water: 1.0 mg/L

Standard Deviation for These Data: ±0.6 mg/L

Conclusions:
A water solubility value of 1.3 mg/l at 23°C (slightly soluble) was determined for the substance using a relevant test method. The result is considered to be reliable.
Executive summary:

Tetradecanol was determined according ASTM E 1148. The water solubility was determined to be 1.3 mg/l at 23 °C.

Endpoint:
water solubility
Type of information:
other: Data obtained from a handbook
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
data is taken from a reliable handbook, information about the methodology is not available
GLP compliance:
not specified
Water solubility:
0.31 mg/L
Conclusions:
A water solubility value of 0.31 mg/L was reported in a handbook which has been subject to peer-review and in which the original data sources are traceable. The result is considered to be reliable.
Endpoint:
water solubility
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Remarks:
The value was predicted using a multiple partitioning model, supported by additional validation.
Principles of method if other than guideline:
Method: other: (calculated) partition model
GLP compliance:
no
Water solubility:
0.2 mg/L
Temp.:
25 °C

The water solubility is estimated to be 0.202 mg/l at a loading rate of 1000 mg/l.

Conclusions:
A water solubility value of 0.2 mg/L was obtained at 25°C using an accepted calculation method. The result is considered to be reliable.
Endpoint:
water solubility
Type of information:
other: Data obtained from a secondary source
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
GLP compliance:
not specified
Water solubility:
0.31 mg/L
Temp.:
25 °C
Conclusions:
A water solubility value of 0.31 mg/L was reported at 25°C in a secondary source to which reliability could not be assigned.
Endpoint:
water solubility
Type of information:
other: Data obtained from a collection of reliable data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
data is taken from a secondary source, information about the methodology is not available
GLP compliance:
not specified
Water solubility:
0.191 mg/L
Temp.:
25
Conclusions:
A water solubility value of 0.191 mg/L was reported at 25°C in a collection of reliable data which has been subject to peer-review and in which the original data sources are traceable. The result is considered to be reliable.
Endpoint:
water solubility
Type of information:
other: Data obtained from a collection of reliable data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
GLP compliance:
not specified
Water solubility:
0.35 mg/L
Temp.:
25 °C
Conclusions:
A water solubility value of 0.35 mg/L was reported at 25°C in a collection of reliable data which has been subject to peer-review and in which the original data sources are traceable. The result is considered to be reliable.

Description of key information

The water solubility of a commercial sample of tetradecan-1-ol is 1.3 mg/L at 23°C and pH 5.5.

Key value for chemical safety assessment

Water solubility:
1.3 mg/L
at the temperature of:
23 °C

Additional information

A water solubility value of 1.3 mg/L at 23°C and pH 5.5 was determined with the use of a flask method in accordance with ASTM E 1148. The result is considered to be reliable.

It is supported by a value of 0.191 mg/L at 25°C, taken from a reliable and definitive reference source for solubility data (Yalkowsky and He, 2003), and consistent results from other reference sources. These results are supported by a predicted water solubility value of 0.2 mg/l at 25°C which was obtained for the substance using a validated QSAR estimation method

The value taken from literature for pure alcohol (0.191 mg/l) is used in exposure modelling.

All the available results indicate that tetradecan-1-ol is slightly soluble in water.

Discussion of trends in the Category of C6-24 linear and essentially-linear aliphatic alcohols:

As chain length increases, water solubility decreases, because the free energy required for a molecule to dissolve becomes less favourable for larger molecules.

Reference:

Yalkowsky,FH & He,Y. 2003. Handbook of Aqueous Solubility Data. CRC Press, Boca Raton, FL (ISBN 0-8493-1532-8)