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EC number: 204-000-3
CAS number: 112-72-1
Table 1: Irritant/corrosive
response data for each animal at each observation time up to removal
of each animal from the test
Score at time point / Reversibility
Max. score: 4
Max. score: 2
Max. score: 3
Average 24h, 48h, 72h
Average time (unit) for reversion
*) Reversibility: c. = completely
= not completely
reversible; n. = not reversible
In the eye irritation study, fine powder of test material was applied
into the eyes of 3 rabbits. Assesment of ocular damage/irritation was
made approximately 1 hour, 24, 48 and 72 hours following treatment.
Total observation period was 14 days.
Diffuse corneal opacity was noted in 2 treated eyes at the 24, 48, and 72 hour observations.
Iridial inflammation was noted in 2 treated eyes at the 24 hour observation and persisted in 1 treated eye at the 48 and 72 hour observations.
Moderate conjunctival irritation was noted in all treated eyes 1 hour after treatment and persisted in 2 treated eyes at the 24 and 48 hour observations. Minimal conjunctival irritation was noted in 1 treated eye at the 24 and 48 hour observations and in 2 treated eyes at the 72 hour and 7 day observation.
Overall irritation score: Maximum group mean score 27.3 at 24 hours.
All corneal and iridial scores and scores for conjunctival chemosis were normal by day 7. Conjunctival redness persisted in 2
rabbits through day 7 but scores were 0 by day 14. The effects were therefore fully reversible.
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