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EC number: 204-000-3
CAS number: 112-72-1
Table 1. Results of definitive study
Tetradecanol concentration (mg/kg dw)
% inhibition (+ve figures) or stimulation (-ve figures) of biological activity compared to solvent controls
concentration (mg/kg dw)
No reliable, standard tests of soil microbial inhibition are available.
A 2-h EC50 value of >1000 mg/kg dwt is available from a non standard
study of non assignable reliability.
A 2-h EC50 value of >1000 mg/kg dwt in soil based on effects
on dehydrogenase activity (as an indirect indicator of microbial
biomass) was observed in a non-standard study (Shell, 2004).
Whilst fully consistent with expectations, this cannot be considered to
be key data.
The terrestrial chemical safety assessment has been conducted using the
Equilibrium Partitioning method (EQPM). It is recognised that the
aquatic PNEC used in the EQPM does not take into account any indicator
for effects in aquatic microorganisms. However, analogous alcohols
within the Category are very rapidly biodegradable and show no
significant inhibitory effects on respiration of activated sludge or
specific microbial strains relevant to WWTP, at or above the limit of
solubility (based on inhibition tests and lack of toxicity in ready
biodegradability test). Therefore it is unlikely that the
PNECterrestrial based on aquatic ecotoxicity test results would not be
protective for terrestrial microorganisms. The chemical safety
assessment using EQPM does not suggest any unacceptable risks for the
Therefore, further toxicity testing with terrestrial microorganisms does
not need to be conducted.
Moreover, considerable technical difficulties would be expected in the
conduct of such a test, due to the very rapid biotic removal of the
substance from the test system. Please refer to discussion of the
long-term aquatic invertebrate and fish studies, and evidence of rapid
removal in non-sterilised soils during method development for the
adsorption/desorption study with natural soils in the environmental fate
A lack of toxicity to soil microbiota was suggested by a recent
experimental finding associated with a recent study of
adsorption/desorption (OECD 106, Wildlife International, 2015) using
decan-1-ol. Significant technical difficulties were encountered during
method development for this study using natural standard soils, in that
it was not possible to detect sufficient substance and establish
equilibrium in non-sterilised soil samples.
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