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EC number: 204-000-3
CAS number: 112-72-1
Table 1. Results of definitive study
Tetradecanol concentration (mg/kg dw)
% inhibition (+ve figures) or stimulation (-ve figures) of biological activity compared to solvent controls
concentration (mg/kg dw)
Short term terrestrial toxicity
Whilst fully consistent with expectations, this cannot be considered to
be key data.
This data is considered to be indicative only (non assignable
reliability) and not suitable for quantitative application as part of
the chemical safety assessment.
Long term terrestrial toxicity
In accordance with Column 2 of REACH Annex IX toxicity testing with terrestrial
microorganisms (required in Section 9.4.2) is not needed as the chemical
safety assessment according to Annex I indicates that this is not
Moreover, considerable technical difficulties would be expected in the
conduct of such a test, due to the very rapid biotic removal of the
substance from the test system. Please refer to discussion of the
long-term aquatic invertebrate and fish studies, and evidence of rapid
removal in non-sterilised soils during method development for the
adsorption/desorption study with natural soils, carried out with the
close structural analogue decan-1-ol, in the environmental fate section.
The terrestrial chemical safety assessment has been conducted using the
Equilibrium Partitioning method (EQPM). It is recognised that the
aquatic PNEC used in the EQPM does not take into account any indicator
for effects in aquatic microorganisms. However, analogous alcohols
within the Category are very rapidly biodegradable and show no
significant inhibitory effects on respiration of activated sludge or
specific microbial strains relevant to WWTP, at or above the limit of
solubility (based on inhibition tests and lack of toxicity in ready
biodegradability test). A lack of toxicity to soil microbiota was
suggested by a recent experimental finding associated with a recent
study of adsorption/desorption (OECD 106, Wildlife International, 2015)
using decan-1-ol. Significant technical difficulties were encountered
during method development for this study using natural standard soils,
in that it was not possible to detect sufficient substance and establish
equilibrium in non-sterilised soil samples.Therefore it is
unlikely that the PNECterrestrial based on aquatic ecotoxicity test
results would not be protective for terrestrial microorganisms. The
chemical safety assessment using EQPM does not suggest any unacceptable
risks for the terrestrial compartment.
Therefore, further toxicity testing with terrestrial microorganisms does
not need to be conducted.
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