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EC number: 204-826-4
CAS number: 127-19-5
Developmental toxicity in rabbits
after inhalation exposure to N,N-dimethylacetamide
Data related to main groups
Rabbits with abort
% post-implantation loss
Placental weight m&f (g)
Placental weight/litter (g)
Litter weight (g)
Fetal weight m and f (g)
% fetuses/litter with soft tissue malformations
% fetuses/litter with soft tissue variations
% fetuses/litter with skeletal variations
*: p<0.05; **: p<0.01
The test substance was investigated for its teratogenic potential in female Humalayan rabbits exposed by inhalation (study report of BG Chemie, 1989; published by Klimish and Hellwig, 2000). Fifteen animals per dose group and control group were used and exposed to 0.2, 0.7, and 2.0 mg/l (equivalent to 0, 57, 200 or 570 ppm) for 6 hours/day from GD7-19 and sacrified at GD29. Two satellite groups exposed to 0 or 2.0 mg/L with 5 animals per group were observed for clinical signs, lethality and body weight until GD20 and clinical chemistry, gross pathology and histopathological investigation of the liver were performed. Maternal animals of the main groups were observed for clinical signs, body weight, lethality, weight of uterus, gross pathology, implants, and corpora lutea. Fetuses were examined for number, weight, sex, weight of placenta, external observations, soft tissue observations including observations of the head, and skeletal observations.
Maternal toxicity was not obseved neither in main groups nor in satellite groups.
Fetotoxic effects were caused at a concentration of 0.7 mg/L (increased skeletal variations, e.g. fused sternebrae and accessory ribs), but there was no statistically significant increase in total skeletal variations. At 2.0 mg/L fetotoxic effects (e.g., significantly decreased fetal and placental weights, increase in soft tissue and skeletal variations) and also signs of a weak teratogenic effect expressed as a marginal, statistically not significant increase in soft tissue malformations (regarding the heart and great vessels) were observed. No compound-related effects were observed in the fetuses after exposure to 0.2 mg/l. Thus, the highest concentration tested under these conditions (2.0 mg/1) was found to be a no-observable-adverse-effectlevel (NOAEL) for the maternal Himalayan rabbit, whereas 0.2 mg/L was defined as the NOAEL for the developing organism.
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