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EC number: 204-826-4
CAS number: 127-19-5
Groups of 8 male and 8 female ChR-CD rats were exposed for 1 h to
time weighted concentrations of: 3.4 (measured range 2.4-4.8), 5.8
(3.8-22.9), or 8.8 (6.6-13.0) mg/L. The test substance was
syringe-driven into a spraying system nebulizer. The post exposure
observation period was 14 days. No mortality was found in males at any
exposure concentration. Females were more susceptible than males. At 8.8
mg/L 4 out of 8 females died within 48 h but no deaths were seen at the
low and mid dose level. No clinical signs were recorded except
hyperactivity in females on day 3-7 after exposure. Initial reduction in
body weight was detected in males at >= 5.8 mg/L and in females at 8.8
mg/L. Conclusion: The LC50 (1 h) in female rats was estimated to be 8.8
mg/L; no mortality was seen in male rats at the time weighted average of
8.8 mg/L. The LC50(1 hour) of DMAC was determined to be 8.8 mg/L
in female rats. Female rats were more susceptible than males.
However, in this study conspicuous variations in dose levels were
obvious and exclusive exposure to vapour (as mentioned by the authors)
was not clear.
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