Registration Dossier
Registration Dossier
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EC number: 204-826-4 | CAS number: 127-19-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No guideline study but scientific standards were met with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Principles of method if other than guideline:
- LD50 in male and female mice after i.p. injection.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- N,N-dimethylacetamide
- EC Number:
- 204-826-4
- EC Name:
- N,N-dimethylacetamide
- Cas Number:
- 127-19-5
- Molecular formula:
- C4H9NO
- IUPAC Name:
- N,N-dimethylacetamide
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: dimethylacetamide (DMAC)
No details available.
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No details available.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 2500, 3200, 4000 µL/kg bw
- No. of animals per sex per dose:
- 5 mice
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
No further details available. - Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 500 other: µL/kg bw
- Remarks on result:
- other: for males and females combined, corresponding to 3290 mg/kg bw
- Mortality:
- Mice died mainly within 2 days. No further details.
- Clinical signs:
- Increased respiration rate, staggered gait, mice crouched down, dyspnoe, ruffled coat, prone position, tremor and reddened eyes were noted. There were no clinical signs after 9 days.
- Body weight:
- No data
- Gross pathology:
- There was suspicion of fatty liver in a few mice.
- Other findings:
- No
Applicant's summary and conclusion
- Conclusions:
- The LD50 of DMAC after i.p. injection was determined to be 3290 mg/kg bw in male and female mice.
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