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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No guideline study but scientific standards were met with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Principles of method if other than guideline:
LD50 in male and female mice after i.p. injection.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N-dimethylacetamide
EC Number:
204-826-4
EC Name:
N,N-dimethylacetamide
Cas Number:
127-19-5
Molecular formula:
C4H9NO
IUPAC Name:
N,N-dimethylacetamide
Test material form:
liquid
Specific details on test material used for the study:
- Name of test material: dimethylacetamide (DMAC)
No details available.

Test animals

Species:
mouse
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
No details available.

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
2500, 3200, 4000 µL/kg bw
No. of animals per sex per dose:
5 mice
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days

No further details available.
Statistics:
No data

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
3 500 other: µL/kg bw
Remarks on result:
other: for males and females combined, corresponding to 3290 mg/kg bw
Mortality:
Mice died mainly within 2 days. No further details.
Clinical signs:
Increased respiration rate, staggered gait, mice crouched down, dyspnoe, ruffled coat, prone position, tremor and reddened eyes were noted. There were no clinical signs after 9 days.
Body weight:
No data
Gross pathology:
There was suspicion of fatty liver in a few mice.
Other findings:
No

Applicant's summary and conclusion

Conclusions:
The LD50 of DMAC after i.p. injection was determined to be 3290 mg/kg bw in male and female mice.