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Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.

Key value for chemical safety assessment

Additional information

The toxicity of N,N-dimethylacetamide (CAS 127-19-5) to microorganisms was investigated in a study conducted equivalent to OECD 209, but using activated sludge from an industrial wwtp. The 30-min EC10 was determined to be greater than 1995 mg/L based on the respiration rate (BASF AG, 1980; report no. 1168; cited in OECD SIDS, 2001). These data were selected as key data for the chemical safety assessment.


A further study was conducted with the single species Pseudomonas putida according to DIN 38412-27. A 16-h LOEC of 4850 mg/L could be determined, supporting the data of the key study. As the original report of this study is not available, the exposure duration was assumed to be 16 hours (BASF AG, 1986; report no. 312186; cited in OECD SIDS, 2001).


Based on the available experimental data, N,N-dimethylacetamide (CAS 127-19-5) is concluded to not inhibit the degradation activity of activated sludge when introduced in appropriately low concentrations.