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EC number: 204-826-4
CAS number: 127-19-5
a chronic dermal toxicity study comparable to guideline (OECD TG 452) 2
dogs per dose level received 0, 0.10, 0.32, 1.0, or 4.0 mL/kg bw/day
corresponding to 0, 94, 300, 940, 3760 mg/kg bw/day to clipped skin. The
dermal exposure was conducted openly with washing after 5 h exposure at
5 days per weeks. The exposure period was 6 weeks for the two higher
dose levels (lethal effects) and 6 months for the two lower dose levels.
Mortality was observed
at the two higher dose levels; dogs died or were sacrificed moribund
(after 6 weeks at 1 mL/kg bw/day). At a dose level of 0.32 mL/kg bw/day
local effects (ulcer), decrease in body weight, increased activity of
alkaline phosphatase, and altered BSP retention were seen. Fatty
degeneration of the liver was detected in histopathology at >=1 mL/kg
bw/day (940 mg/kg bw/day). No data were available on histopathology of
the testes (compare with other repeated dose studies in mouse and rat).
Conclusion: The dermal NOAEL was 94 mg/kg bw/day.
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