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EC number: 204-826-4
CAS number: 127-19-5
Data on acute inhalation toxicity in Section
7.2.3 suggested no toxic effects at a dose level of 700 ppm.
The Tier II mutagenic screening of the test substance was conducted
according to OECD 475 in 1980. GLP compliance was not specified. A
cytogenetic analysis of rat bone marrow cells was performed after in
vivo exposure to 20 or 700 ppm of the test substance for seven hours per
day for 1 or 5 days in male and female rats. A positive (single gavage
with 250 mg/kg bw ethyl methanesulfonate) control and a negative control
was included. Sampling times were 6 h, 24 h, and 48 h post-exposure. The
frequencies of chromosomal aberrations were not increased significantly
in the rat bone marrow cells.
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