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EC number: 204-826-4
CAS number: 127-19-5
Elimination of workplace exposure to DMAC resulted in a
decline of elevated ALT levels.
In the study, 1045 workers exposed to DMAC from January 2001 to July
2004 in 2 plants producing polyurethane elastic fibres and using DMAC as
solvent are described. A pre-placement health examination,
post-placement health examinations every 10 days for the next three
months, and semi-annual periodic health examinations thereafter were
performed; pre-placement health examination included hepatic function
tests, AST, ALT, and y-glutamyl transpeptidase (GGT) and tests for viral
hepatitis; urine NMAC (N-methylacetamide, marker for DMAC exposure) were
tested at the semi-annual periodic health examinations. Urine sampling
was conducted only during the period 2003-2004. 228 urinary NMAC results
were collected from the department with hepatic injuries related to DMAC
exposure (1056 samples from other department, presumably not exposed, no
details given); urine sampling after shift.
The study meets scientific standards but correlation
between DMAC exposure and hepatotoxic effects was not clear (exposure
was related to the biological exposure index of 30 mg NMAC/g creatinine
but urine sampling was conducted only during the second half of the
monitoring period; there were no data about inhalation exposure
concentration or dermal exposure; low number of urine samples).
Data on biological exposure index are not suitable for
quantitative estimation of DMAC exposure (samples related to the
corresponding department of the plant but not to the DIHI cases; urine
samples were only available during the second half of the monitoring
period; no clear difference between control and DIHI values).
There were some indications for DMAC-induced hepatic injuries in 38 out
of 1045 monitored workers but no sufficient quantitative data on
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