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EC number: 204-826-4
CAS number: 127-19-5
Long-term toxicity to aquatic invertebrates is not expected.
QSAR-disclaimer:In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.For the assessment of the substance, (Q)SAR results were used for the estimation of the long-term toxicity on aquatic invertebrates. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.Therefore, further experimental studies on the long-term toxicity to vertebrates are not provided.Assessment:The long-term toxicity on aquatic invertebrates has been assessed using the OECD QSAR Toolbox v4.4. A 21-d NOEC for reproduction of Daphnia magna was derived using a trend analysis of the standardized workflow for ecotoxicological endpoints as provided by the Toolbox. The resulting 21-d NOEC was 56.8 mg/L. The Substance is within the applicability domain of the model. A robust study summary for this endpoint has been provided, which contains all relevant and required information. It can be concluded that long-term toxicity on aquatic invertebrates is not expected. Therefore, the Registrant will not perform a study on the long-term toxicity to aquatic invertebrates.
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