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Short-term toxicity to aquatic invertebrates

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Description of key information

With high probability acutely not harmful to aquatic invertebrates.

Key value for chemical safety assessment

Additional information

Considering the toxicity of N,N-dimethylacetamide to aquatic invertebrates there are experimental data from two studies for each, the freshwater and marine compartment available.

 

Freshwater data:

- In a static test conducted according to EU method C.2., using D. magna as test organism, a 48-h EC50 of >500 mg/L was determined, based on nominal test concentrations (BASF AG, 1988; report no. 1/1021/2/88-1021/88). These data were selected as freshwater-key data.

- In a supporting acute toxicity test (guideline not specified in study report) with D. magna as test organism, the 48-h EC50 was >1000 g/L (nominal, Adema, 1987; cited in OECD SIDS, 2001).

 

Marine data:

- A semi-static acute toxicity test (guideline not specified in study report) was conducted using Americamysis bahia (former: Mysidopsis bahia) as test organism. Based on nominal test concentrations the 96-h EC50 was found to be 966 mg/L (Adema, 1987; cited in OECD SIDS, 2001). These data were selected as key-marine data.

 - In a further acute toxicity test conducted under marine conditions (guideline not specified in study report) the test organism was chaetogammarus marinus. After an exposure period of 96 h the EC50 was determined to be >1000 mg/L, supporting the results of the marine key study (Adema, 1987; cited in OECD SIDS, 2001).

In conclusion, the substance is assessed to be with probability acutely not harmful to aquatic invertebrates.