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EC number: 204-826-4
CAS number: 127-19-5
Table 2: Skin erythema in 2 rabbits after dermal exposure to the undiluted test substance for 20 h
Time after initiation of exposure
20 hours exposure; erythema in
Rabbit 1 (f)
Rabbit 2 (m)
- Evaluation transformed to OECD-Draize scoring; no edema reported (no abnormality detected).
study according to a BASF internal standard method comparable to OECD
404, two rabbits were dermally exposed to undiluted liquid test
substance (ca. 1 mL) for 1, 5, 15 minutes or for 20 h to the back skin.
The coverage was occlusive; the skin was washed after exposure (not
after the exposure period of 20 h). Skin reaction was scored 24, 72, 96
h and 7 days after initiation.
substance had only slight skin irritant properties after an exposure
period of 20 h. Questionable to slight reddening was found after 1-15
minutes of exposure, effects were reversible 48-96 h after exposure.
After the 20 h exposure period no edema was seen in any test animal. At
all time points for scoring not more than a questionable reddening (OECD
score 1) was detected, which was reversible after 7 days. One rabbit
showed a fine scaling 7 days after application. Therefore, the test
substance was considered to be no skin irritant.
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