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EC number: 204-826-4
CAS number: 127-19-5
Short-term toxicity to fish:
The toxicity of N,N-dimethylacetamide to fish was investigated in a static test conducted according to DIN 38412, part 15 using Leuciscus idus as test organism (BASF AG, 1979; report no. 78/277). Based on nominal test concentrations the 96-h LC50 was found to be >500 mg/L. These data were selected as key data in terms of the chemical safety assessment.
In conclusion, N,N-dimethylacetamide (CAS 127-19-5) is concluded to be with high probability acutely not harmful to fish.
Long-term toxicity to fish:
No experimental data available.
Based on an acute-to-chronic ratio (ACR), the intrinsic properties of the Substance indicate that significant and relevant long-term effects on fish will not occur (NOEC > 1 mg/L).
Short-term toxicity to aquatic invertebrates:
Considering the toxicity of N,N-dimethylacetamide to aquatic invertebrates there are experimental data from two studies for each, the freshwater and marine compartment available.
- In a static test conducted according to EU method C.2., using D. magna as test organism, a 48-h EC50 of >500 mg/L was determined, based on nominal test concentrations (BASF AG, 1988; report no. 1/1021/2/88-1021/88). These data were selected as freshwater-key data.
- In a supporting acute toxicity test (guideline not specified in study report) with D. magna as test organism, the 48-h EC50 was >1000 g/L (nominal, Adema, 1987; cited in OECD SIDS, 2001).
- A semi-static acute toxicity test (guideline not specified in study report) was conducted using Americamysis bahia (former: Mysidopsis bahia) as test organism. Based on nominal test concentrations the 96-h EC50 was found to be 966 mg/L (Adema, 1987; cited in OECD SIDS, 2001). These data were selected as key-marine data.
- In a further acute toxicity test conducted under marine conditions (guideline not specified in study report) the test organism was chaetogammarus marinus. After an exposure period of 96 h the EC50 was determined to be >1000 mg/L, supporting the results of the marine key study (Adema, 1987; cited in OECD SIDS, 2001).
In conclusion, the substance is assessed to be with probability acutely not harmful to aquatic invertebrates.
Long-term toxicity to aquatic invertebrates:
The long-term toxicity on aquatic invertebrates has been assessed using the OECD QSAR Toolbox v4.4. A 21-d NOEC for reproduction of Daphnia magna was derived using a trend analysis of the standardized workflow for ecotoxicological endpoints as provided by the Toolbox. The resulting 21-d NOEC was 56.8 mg/L. The Substance is within the applicability domain of the model. A robust study summary for this endpoint has been provided, which contains all relevant and required information. It can be concluded that long-term toxicity on aquatic invertebrates is not expected. Therefore, the Registrant will not perform a study on the long-term toxicity to aquatic invertebrates.
Toxicity to aquatic algae and cyanobacteria:
In a non-GLP, 72 -hour static test with the green algae Desmosdemus subspicatus according to a national standard method (German Industrial Standard DIN 38412, Part 9), the algal toxicity of N,N-dimethylacetamide was studied. The original data were statistically re-evaluated using Toxrat Pro v2.09. Based on growth rate an EC50 (72 h) of > 500 mg/L and a NOEC (72 h) of >= 500 mg/L were determined (BASF AG, 1989/2007. Report No. 2/1021/88) indicating the substance to be with high probability acutely not harmful to aquatic algae.
Toxicity to microorganisms:
The toxicity of N,N-dimethylacetamide (CAS 127-19-5) to microorganisms was investigated in a study conducted equivalent to OECD 209, but using activated sludge from an industrial wwtp. The 30-min EC10 was determined to be greater than 1995 mg/L based on the respiration rate (BASF AG, 1980; report no. 1168; cited in OECD SIDS, 2001). These data were selected as key data for the chemical safety assessment.
A further study was conducted with the single species Pseudomonas putida according to DIN 38412-27. A 16-h LOEC of 4850 mg/L could be determined, supporting the data of the key study. As the original report of this study is not available, the exposure duration was assumed to be 16 hours (BASF AG, 1986; report no. 312186; cited in OECD SIDS, 2001).
Based on the available experimental data, N,N-dimethylacetamide (CAS 127-19-5) is concluded to not inhibit the degradation activity of activated sludge when introduced in appropriately low concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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