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EC number: 204-826-4
CAS number: 127-19-5
Prior to the permeability test, no leakage of skin and
cell viability was given. Skin cell viability was checked after the
permeability test (DNA synthesis as measured by incorporation of BrdU);
Result: no labelling of cells (not clearly discussed by
A normalization procedure was used to assess the effects
of 3H-water on permeability: after normalisation the permeability
constant was 217 ± 84 g/m²/h.
In in vitro skin absorption experiments, the skin of a
female donor was used. Viability and skin integrity check was performed
prior to experiments. In the diffusion cell the skin was exposed to
undiluted test substance and 0.5 mL samples of receptor fluid were
collected 0.16, 0.33, 0.5 (or 0.66), 1, 2, 4, 6 h after application of
the test substance. Totally 3 trials were performed.
The authors calculated a permeability constant of 107 ±
19 g/m²/h (mean ± SD of 3 trials).
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