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EC number: 204-826-4
CAS number: 127-19-5
No data available.
The toxic effects of N,N-dimethylacetamide
was tested in a screening test (similar to OECD 207; short-term exposure
on filter paper) with the earthworm Eisenia fetida. The substance was
found to be very toxic to the earthworm (LC50 (48 h): 0.01 -0.1 mg/cm²)
(Roberts & Dorough, 1984). However, due to major methodological
deficencies and because the results are only given as mg/cm² filter
paper which can't be recalculated as mg/kg soil dw, the study was
disregarded in terms of chemical safety assessment.
In Annex X section 9.4 of Regulation (EC) No
1907/2006, it is laid down that tests on terrestrial organisms shall be
proposed by the registrant if the chemical safety assessment indicates
the need to investigate further the effects on terrestrial organisms.
According to Annex I of this regulation, the chemical safety assessment
triggers further action when the substance or the preparation meets the
criteria for classification as dangerous according to Regulation EC
1272/2008 or is assessed to be a PBT or vPvB. The hazard assessment of
the substance reveals neither a need to classify the substance as
dangerous to the environment, nor is it a PBT or vPvB substance.
Furthermore, according to Annex X section
9.4 of Regulation (EC) No 1907/2006, those studies do not need to be
conducted if direct or indirect exposure of the soil compartment is
unlikely. The substance is considered to be only industrially used.
Therefore, direct exposure to the soil compartment is unlikely. In
addition, indirect exposure to soil is unlikely since the substance is
readily biodegradable (but without fulfilling the 10-day window
criterion). For substances being considered as „readily biodegradable“,
it can be assumed that they will be biologically degraded within the
STP-process. As the log Koc and log Pow of the substance is below 3 and
no cationic and surface-active properties are given a low adsorption
potential is indicated. Hence, an adsorption to soil unlikely and, as a
consequence, a transfer to the soil compartment is unlikely.
Therefore, and for reasons of animal
welfare, no further tests on terrestrial organisms are provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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