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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Classification & Labelling & PBT assessment

PBT assessment

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Administrative data

PBT assessment: overall result

PBT status:
the substance is not PBT / vPvB

N,N-dimethylacetamide (CAS 127-19-5) is readily biodegradable according to OECD criteria, therefore the substance is not P or vP. The substance does not accumulate in organisms, based on a measured Log Kow of -0.77 and is, therefore, not B or vB. The substance is also not T since the lowest available chronic value is > 0.01 mg/L (algae: 72-h NOErC ≥ 500 mg/L). However, due to effects on reproduction of mammals (category repr. 1B; H360D) the substance has to be regarded as toxic.


In summary, the substance does not fulfill the PBT and vPvB criteria.