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EC number: 203-466-5
CAS number: 107-13-1
Testicular damage was observed in mice gavaged with 10 mg/kg bw/d
acrylonitrile, consisting of tubular atrophy and degeneration in
approximately 40% of seminiferous tubules, with cytolysis and nuclear
pyknosis of spermatids, formation of multinucleate giant cells and
interstitial oedema. These changes were accompanied by a decrease in
testicular sorbitol dehydrogenase (22% decrease, p<0.05) and acid
phosphatase (16% decrease p < 0.05) and an increase in lactate
dehydrogenase (12% increase, p < 0.05) and B-glucuronidase (36.7%
increase, p < 0.05). Glucose-6-phosphatase was unaffected. These
changes were seen in the absence of overt signs of toxicity or any
effect on body weight or testicular weight. No effects were seeen in
mice gavaged with 1 mg/kg bw/d acrylonitrile.
Daily oral administration of acrylonitrile (10 mg/kg bw/d) to mice for a
period of 60 days caused a significant decrease in the activity of
testicular sorbitol dehydrogenase and acid phosphatase, and an increase
in that of lactate dehydrogenase and beta-glucuronidase.
Histopathological studies revealed degeneration of the seminiferous
tubules. A decrease in the sperm counts of the epididymal spermatozoa
was also observed in the animals of the acrylonitrile-exposed group. The
authors suggest that acrylonitrile may affect male reproductive function
by causing testicular injury. No effects were seen at a dose level of 1
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