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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published mechanistic study reporting acute LD50 values

Data source

Reference
Reference Type:
publication
Title:
Acute toxicity of some synthetic cyanogens in rats: Time-dependent cyanide generation and cytochrome oxidase inhibition in soft tissues after sub-lethal oral intoxication
Author:
Rao P, Singh P, Kumar Yadav S, Gujar NL & Bhattacharya R
Year:
2013
Bibliographic source:
Food and Chemical Toxicology 59: 595–609

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Dixon’s up and down method
GLP compliance:
no
Remarks:
published study
Test type:
up-and-down procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Acrylonitrile
EC Number:
203-466-5
EC Name:
Acrylonitrile
Cas Number:
107-13-1
Molecular formula:
C3H3N
IUPAC Name:
prop-2-enenitrile
Specific details on test material used for the study:
Not reported

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
Rats were gavaged with acrylonitrile
No. of animals per sex per dose:
6-8 rats were used in total
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
95.1 mg/kg bw
Based on:
test mat.
95% CL:
>= 81.7 - <= 110.6
Remarks on result:
other:
Remarks:
An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported.

Any other information on results incl. tables

An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported.
Executive summary:

The oral LD50 of acrylonitrile was investigated preliminary to mechanistic investigations. 6 -8 female Wistar rats were administered acrylonitrile by gavage according to Dixon’s up and down method. An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported. This value is consistent with other data.