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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published mechanistic study reporting acute LD50 values

Data source

Reference
Reference Type:
publication
Title:
Acute toxicity of some synthetic cyanogens in rats: Time-dependent cyanide generation and cytochrome oxidase inhibition in soft tissues after sub-lethal oral intoxication
Author:
Rao P, Singh P, Kumar Yadav S, Gujar NL & Bhattacharya R
Year:
2013
Bibliographic source:
Food and Chemical Toxicology 59: 595–609

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Dixon’s up and down method
GLP compliance:
no
Remarks:
published study
Test type:
up-and-down procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Acrylonitrile
EC Number:
203-466-5
EC Name:
Acrylonitrile
Cas Number:
107-13-1
Molecular formula:
C3H3N
IUPAC Name:
acrylonitrile
Specific details on test material used for the study:
Not reported

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
Rats were gavaged with acrylonitrile
No. of animals per sex per dose:
6-8 rats were used in total
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
95.1 mg/kg bw
Based on:
test mat.
95% CL:
>= 81.7 - <= 110.6
Remarks on result:
other:
Remarks:
An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported.

Any other information on results incl. tables

An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported.
Executive summary:

The oral LD50 of acrylonitrile was investigated preliminary to mechanistic investigations. 6 -8 female Wistar rats were administered acrylonitrile by gavage according to Dixon’s up and down method. An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported. This value is consistent with other data.