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EC number: 203-466-5
CAS number: 107-13-1
In a case reported in 1961 (Hashimoto and Kobayashi), skin lesions were
observed in humans at the first site of contact with liquid
acrylonitrile, which then spread rapidly to other neighbouring regions.
Several days after contact the lesions spread to other parts of the body
that had not been in contact with the liquid. It was concluded that
these later skin lesions were indicative of an allergic type response to
the initial exposure to acrylonitrile liquid.
A positive patch test for acrylonitrile was determined in 5 employees of
an acrylonitrile processing and production plant who had contact
dermatitis. The 8 control indviduals did not show any allergic reaction
to acrylonitrile (Bakker et al, 1991).
The limited human data indicate that skin sensitisation may occur
following skin contact, however data are scarce. The EU RAR concludes
that acrylonitrile should be classified as a skin sensitiser.
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