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EC number: 203-466-5
CAS number: 107-13-1
Whilst the study is well-conducted, it may have been compromised by SDA
Foetal body weight (g)
Foetal crown-rump length (mm)
* statistically significant (p< 0.05)
Selected developmental anomalies and variants
Number evaluated (foetuses/litters)
Missing or short tail
Right sided aortic arch
Anteriorly displaced ovaries
Missing vertebra (other than 1 thoracic and 1 lumbar)
Missing vertebral centra (other than C1 and C2)
Missing ribs (more than 1 pair)
a F= foetuses; L= litters
b Number affected (% affected)
c Alteration seen only in foetuses that
also showed short or no tail at this dose level
Mated female Sprague-Dawley rats (29 -39/group) were gavaged with
acrylonitrile (in water) at dose levels of 0, 10, 25 or 65 mg/kg bw/d on
Days 6 -15 of gestation. Dams were observed for clinical signs,
bodyweight, food and water consumption. Dams were killed on Day 21 and
the uterine contents examined. All foetuses were examined for external
abnormalities, one third for visceral abnormalities and two thirds for
Mortality, signs of toxicity (hyperactivity and salivation), reduced
weight and food consumption and increased water consumption were noted
in the high dose group. Necropsy revealed gastric irritation in most
animals at 65 mg/kg bw.d and a small number at 25 mg/kg bw/d.
Post-implantation loss was increased at the high dose level; reduced
foetal weight and length was also apparent in this group. No effects
were seeen in the other treated groups. A higher incidence of short tail
was seen in foetuses at 65 mg/kg bw/d, with other abnormalities and
skeletal variations also increased in this group. No effects were seen
in the lower dose groups.
Some evidence of developmental toxiicty was seen in this study at the
highest (and maternally toxic) dose level of 65 mg/kg bw/d. The NOAEL
for maternal toxicitiy is therefore 10 mg/kg bw/d based on the signs of
gastric irritation at 25 mg/kg bw/d; the NOAEL for developmental
toxicity is 25 mg/kg bw/d.
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