Registration Dossier
Registration Dossier
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EC number: 203-466-5 | CAS number: 107-13-1
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity of acrylonitrile to fish was determined in the fish early life stage test, with P. promelas (Fathead minnows using flow-through conditions. No NOEC could be established for this study as the growth rate was significantly reduced at the lowest concentration tested of 0.34 mg/L; a NOEC of 0.17 mg/L is estimated.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.17 mg/L
Additional information
Available data are summarised in the EU RAR. The toxicity of acrylonitrile to fish was determined in the fish early life stage test, with P. promelas (Fathead minnow) using flow-through conditions. No NOEC could be established for this study as the growth rate was significantly reduced at the lowest concentration tested (measured: 0.34 mg/l). The report concluded that this concentration represented the MATC. The EU RAR concludes that this concentration represents the LOEC (for risk assessment purposes). The EU RAR calculates a NOEC by applying an assessment factor of 2 to the LOEC, giving a NOEC of 0.17 mg/l.
A study is also available which investigates the sub-lethal effects of acrylonitrile on Dicentrarchus labrax (seabass). The LOEC based on a number of biomarkers was found to be 0.15 mg/L. This has not been considered for PNEC derivation as the study is not conducted to a known guideline and is of unknown reliability, and has only been presented here for informational purposes (Neuparth et al., 2013).
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