Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
other: published review
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published tudies are summarised reported in EU RAR (2004)

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2004

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute toxicity following exposure to acrylonitrile by other routes of administration
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: various: values are reported for the mouse, rat, hamster, guinea pig and rabbit.
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: various: intraperitoneal, subcutaneous and intraveneous
Vehicle:
not specified
Doses:
No information available
No. of animals per sex per dose:
No information available
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
47 - 50 mg/kg bw
Remarks on result:
other: Mouse intraperitoneal
Sex:
not specified
Dose descriptor:
LD50
Effect level:
65 - 100 mg/kg bw
Remarks on result:
other: Rat intraperitoneal
Sex:
not specified
Dose descriptor:
LD50
Effect level:
25 - 50 mg/kg bw
Remarks on result:
other: Mouse subcutaneous
Sex:
not specified
Dose descriptor:
LD50
Effect level:
35 mg/kg bw
Remarks on result:
other: Mouse subcutaneous
Sex:
not specified
Dose descriptor:
LD50
Effect level:
60 mg/kg bw
Remarks on result:
other: Hamster subcutaneous
Sex:
not specified
Dose descriptor:
LD50
Effect level:
80 - 96 mg/kg bw
Remarks on result:
other: Rat subcutaneous
Sex:
not specified
Dose descriptor:
LD50
Effect level:
100 mg/kg bw
Remarks on result:
other: Rat subcutaneous
Sex:
not specified
Dose descriptor:
LD50
Effect level:
130 mg/kg bw
Remarks on result:
other: Guinea pig subcutaneous
Sex:
not specified
Dose descriptor:
LD50
Effect level:
69 mg/kg bw
Remarks on result:
other: Rabbit intraveneous
Sex:
not specified
Dose descriptor:
LD50
Effect level:
72 mg/kg bw
Remarks on result:
other: Guinea pig intravenous

Any other information on results incl. tables

The LD50 values for acrylonitrile administered by parenteral routes are broadly comparable with the reported acute oral LD50 values.

Applicant's summary and conclusion

Conclusions:
The LD50 values for acrylonitrile administered to various species by parenteral routes are broadly comparable with the reported acute oral LD50 values.
Executive summary:

LD50 values are reported for acrylonitrile administered via the subcutaneous, intraperitoneal or intravenous routes to rats, guinea pigs, hamsters, mice and rabbits. The values for these routes of administration are similar to those for oral administration and therefore are consistent with rapid and extensive absorption following oral administration.