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EC number: 203-466-5
CAS number: 107-13-1
Clinical observations (number of animals with finding) made
immediately following exposure.
Vocalisation upon handling
M = male, F = female
* noted as a sudden jump from the animal's original position.
Clinical observations (number of occurrences/number of animals) noted
during the 14 day exposure period.
The acute inhalation toxicity of acrylonitrile in the rat was determined
using a single 4 hour, nose-only exposure. The animals were 5 male and 5
female Crl:CD (SD) albino rats per concentration. The rats were exposed
to acrylonitrile vapour at concentrations of 539, 775, 871, 1006 and
1181 ppm, at which mortality was 0/10, 0/10, 4/10, 7/10 and 9/10
animals, respectively. All deaths occurred within 2 days of exposure.
Ataxia, laboured breathing, hypoactivity and gasping were noted
immediately following exposure. Bodyweights decreased from Day 0 to Day
1 in all animals except 1 female in the 539 ppm group. Initial
bodyweight was surpassed in all surviving animals by Day 14. Macroscopic
findings noted in the 871 and 1006 ppm for animals that died were
distended, gas-filled stomach and/or jejunum. For animals found dead in
the 1181 ppm group, dark red discoloration of the lungs was observed .
At the scheduled necropsy, dark red discoloration of the lungs was noted
for one male in the 871 ppm group. There were no other gross findings at
the scheduled necropsy of animals that survived.
Based on the results of this study, the LC50 of acrylonitrile was
calculated to be 946 ppm when male and female albino rats were exposed
to a nose-only acrylonitrile vapour for a single, 4-hour period.
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