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EC number: 203-466-5
CAS number: 107-13-1
Reported LC50 values for various terrestrial arthrpod species were in the range 0.1 to 6.5 mg/l acrylonitrile.
The EU RAR reviews several studies conducted to assess
the toxic effects of acrylonitrile when applied as a fumigant (in air)
to various arthropod species known to infest food products.
The 8 hour LC50 for Sitophilus granarius, Tribolium
confusum, Tenebrioides mauritanicus was 0.7 - 2.8 mg/l.
The 2 hour LC50 was 2 - 6.5 mg/l, and the 6 hour LC50 was
0.8 - 2.0 mg/l in Sitophilus oryza, Zabrotes pectoralis, Stegobium
paniceum, Acanthoscelides obtectus, Oryzaephilus
surinamensis and Rhyzopertha dominica.
The pupae of Callosobruchus chinensis were found
to be more resistant to acrylonitrile than the eggs, larvae or adults,
with a 24 hour LC50 of 1.26 mg/l compared to approximately 0.1 mg/l,
An LC50 of 0.8 - 1.1 mg/l was reported for adults and
larvae of Tribolium castaneum and larvae of Trogoderma
granarium. The LC50 concentrations of acrylonitrile significantly
inhibited the enzymes trehalase and phosphorylase in both species. Sub-lethal
concentrations had similar effects on Tribolium castaneum adults
but had less effect on these enzymes at the larval stages in either
soecies, and had no effect on acetylcholinesterase.
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